Melendez and Thomson first met in June 2008 with the Strikeforce lightweight title on the line, and Thomson got the best of his old friend and training partner winning a unanimous decision.
A year and a half later, Melendez got his revenge by besting Thomson in the rematch also winning a unanimous decision.
Now the pair will meet for a third time coming up in May to settle the rivalry once and for all.
Melendez vs. Thomson III will be the co-headline feature on the May 19 card, with the main event pitting Josh Barnett vs. Daniel Cormier in the finals of the Strikeforce Heavyweight Grand Prix.
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